2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7603
    Rubrofusarin triglucoside 245724-07-6 98%
    Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC50 of 85.5 μM.
    Rubrofusarin triglucoside
  • HY-N7708
    Lycodoline 6900-92-1 98%
    Lycodoline is a alkaloid with butyrylcholinesterase (BChE) (IC50 of 667 μM) inhibition activities.
    Lycodoline
  • HY-N7751
    Isotanshinone II 98249-39-9 98%
    Isotanshinone II is a natural product that can be isolated from Salvia glutinos. Isotanshinone II can be used to study Alzheimer's disease.
    Isotanshinone II
  • HY-N7780
    Aflatrem 70553-75-2 98%
    Aflatrem is a mycotoxin that can be isolated from Aspergillus flavus. Aflatrem has acute neurotoxic effects and can be ued in neurological disease.
    Aflatrem
  • HY-N7965
    Methyl kakuol 70342-29-9 98%
    Methyl kakuol shows agonistic activity against TRPA1 with an EC50 of 0.27 µM.
    Methyl kakuol
  • HY-N7966
    Bacopaside N2 871706-75-1 98%
    Bacopaside N2 is a diglycosidic saponin.
    Bacopaside N2
  • HY-N8018
    Leucosceptoside A 83529-62-8 98%
    Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against α-glucosidase and PKCα (IC50 of 19.0 μM).
    Leucosceptoside A
  • HY-N8103
    Heishuixiecaoline A 1469493-85-3 98%
    Heishuixiecaoline A is a germacrane-type sesquiterpenoid. Heishuixiecaoline A shows protective effect on the neurotoxicity of PC12 cells induced by Aβ25-35.
    Heishuixiecaoline A
  • HY-N8216
    Bacopaside IV 155545-03-2 98%
    Bacopaside IV is a saponin.
    Bacopaside IV
  • HY-N8222
    Bacopaside N1 871706-74-0 98%
    Bacopaside N1 is a diglycosidic saponin.
    Bacopaside N1
  • HY-N8315
    Echitovenidine 7222-35-7 98%
    Echitovenidine is an alkaloid that can be isolated from Alstonia yunnanensis. Echitovenidine is an inhibitor of monoamine oxidase (MAO).
    Echitovenidine
  • HY-N8412
    4-O-Methylbutein 13323-67-6 98%
    4-O-Methylbutein is a phenolic glucoside that can be isolated from Elsholtzia ciliata.4-O-Methylbutein exhibits neuroprotective effects against glutamate-induced HT22 cell death with an EC50 of 35.2 μM.
    4-O-Methylbutein
  • HY-N8414
    Dehydrogeijerin 16850-91-2 98%
    Dehydrogeijerin is an inhibitor of acetylcholinesterase with an IC50 of 9.7 μM. Dehydrogeijerin can be used in study Alzheimer’s disease.
    Dehydrogeijerin
  • HY-N8422
    1(10)-Aristolen-2-one 28398-06-3 98%
    1(10)-Aristolen-2-one is an agent with sedative effect.
    1(10)-Aristolen-2-one
  • HY-N8453
    Macranthoin G 159934-13-1 98%
    Macranthoin G is an inhibitor of p38 MAPK. Macranthoin G protects the cytotoxicity induced by Aβ or hydrogen peroxide in neuronal cells by downregulating p38 MAPK. Macranthoin G can used in study Alzheimer’s Disease.
    Macranthoin G
  • HY-N8671
    Withanoside V 256520-90-8 98%
    Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum.
    Withanoside V
  • HY-N8730
    7,8,3′,4′-Tetramethoxyflavone 65548-55-2 98%
    7,8,3 ',4 '-Tetramethoxyflavone is an extract isolated from natural pomegranate juice and seeds. 7,8,3 ',4' -Tetramethoxyflavone has a protective effect on the neurotoxicity of paraquat-induced Parkinson's disease mouse model .
    7,8,3′,4′-Tetramethoxyflavone
  • HY-N8755
    Chikusetsusaponin Ib 59252-87-8 98%
    Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor.
    Chikusetsusaponin Ib
  • HY-N8764
    Decaffeoylacteoside 61548-34-3 98%
    Decaffeoylacteoside is an inhibitor of AChE/BChE/LOX with moderate activity.
    Decaffeoylacteoside
  • HY-N8765
    Methyl 2-(5-acetyl-2,3-dihydrobenzofuran-2-yl)propenoate 617722-55-1 98%
    Methyl 2-(5-acetyl-2,3-dihydrobenzofuran-2-yl)propenoate can be isolated from roots of Microglossa Pyrifolia. Microglossa Pyrifolia roots has analgesic and hepatic activities.
    Methyl 2-(5-acetyl-2,3-dihydrobenzofuran-2-yl)propenoate
Cat. No. Product Name / Synonyms Application Reactivity